Huntington’s disease (HD) is prevalent South Africa. Most of the families with HD have Dutch or British ancestry, which suggests they inherited the European HD allele. HD is believed to have first arrived in South Africa more than 300 years ago when Dutch colonists settled into the Western Cape in the 1600s. Thus, the prevalence of HD in South Africa is the result of the founder effect.

Mutations in the HTT gene cause Huntington’s disease. The HTT gene provides instructions for making a protein called huntintin. This protein plays a role in nerve cells in the brain. The HTT mutation that causes HD involves a DNA segment known as a CAG trinucleotide repeat. This segment is made up of a series of three DNA building blocks that appear multiple times in a row. Normally, the CAG segment is repeated 10 to 35 times within the gene. In people with HD, the CAG segment is repeated 36 to more than 120 times. An increase in the size of the CAG segment leads to the production of an abnormally long version of the huntintin protein. This causes the dysfunction and eventual death of neurons in certain areas of the brain. The more repeats, the more serious the disease is.

HD is inherited in an autosomal dominant pattern. There is both an adult onset (after reproductive age) and a juvenile onset pattern. People with adult onset typically have 40 to 50 repeats, while people with the juvenile form tend to have more than 60 repeats. Individuals who have 27 to 35 repeats do not develop HD, but they are at risk of having children who will develop the disorder. As the gene is passed on to offspring, the size of the repeat may lengthen into the range associated with HD.

Predict what will happen to the allele frequencies for Huntington’s disease in South Africa if there were a new mutation to the HTT gene that causes a reduction to the CAG trinucleotide repeat. Justify your prediction with evidence. Your response should include links to the sources of information gathered.

Answers

Answer 1

Answer:

If there were a new mutation to the HTT gene that causes a reduction to the CAG trinucleotide repeat, the allele frequency for Huntington's disease would decrease in South Africa. HD is caused by too many repeats of the CAG segment causing an abnormally long version of the huntintin protein which becomes deadly. so if the number of repeats is reduced then the person is more likely to not have Huntington's disease. If they do still develop Huntington's disease, it will be more likely to be adult onset and they will still have an opportunity to reproduce offspring which may carry the trait for reduced CAG.

Answer 2

If a new mutation in the HTT gene were to cause a reduction in the CAG trinucleotide repeat, the allele frequencies for HD in South Africa would likely decrease over time.

What is mutation?

A mutation is a change in the nucleic acid sequence of an organism's, virus's, or extrachromosomal DNA's genome. Viral genomes can be made up of either DNA or RNA.

If a new mutation in the HTT gene caused a decrease in the CAG trinucleotide repeat, HD allele frequencies in South Africa would likely decrease over time. This is due to the fact that reducing the size of the CAG segment would result in a lower risk of developing HD.

Individuals with CAG repeats in the range of 27-35 do not develop HD, but they may pass on the mutated allele to their offspring, who may develop the disorder if the CAG repeat size exceeds 35.

Therefore, if a new mutation were to arise that reduces the size of the CAG repeat, individuals who carry the mutated allele would be less likely to pass it on to their offspring.

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Related Questions

what are three things that an ecological pyramid shows that food webs
and food chains do not show.

Answers

Answer:

An ecological pyramid shows energy flowing through different ecosystems, the amount of energy that is being passed down, and the amount of organisms.

Explanation:

The three things that are not displayed by food chain and food web but showed by ecological pyramid are;

Energy flowing through different ecosystems.

Amount of organisms.

Amount of energy that is being passed down.

An ecological pyramid can be regarded as graphical representation that display relationship between different organisms in an ecosystem.

The trophic levels in this ecological pyramid contains amount of organisms as well as mass which is biomass and the amount of energy that can be found in each level.

Therefore, it shows the energy flowing through different ecosystems.

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Difference between phagocytosis and lymphocytes

Answers

Answer:

The main difference between lymphocytes and phagocytes is that lymphocytes generates specific immune responses against pathogens whereas phagocytes generate the same response to any pathogen.

Explanation:

This means lymphocytes are the tools of the adaptive immunity whereas phagocytes are the tools of innate immunity

The main difference between lymphocytes and phagocytes is that lymphocytes generate specific immune responses against pathogens whereas phagocytes generate the same response to any pathogen. This means lymphocytes are the tools of the adaptive immunity whereas phagocytes are the tools of innate immunity

what is Reticulum? where we can find it? ​

Answers

Answer:   Endoplasmic reticulum (ER), in biology, a continuous membrane system that forms a series of flattened sacs within the cytoplasm of eukaryotic cells and serves multiple functions, being important particularly in the synthesis, folding, modification, and transport of proteins .

Answer:

A reticulum is the second compartment of the stomach of ruminant mammals, lined with a membrane having honeycombed ridges. In the stomach.

Explanation:

A gene mutation changes a section of DNA whereas a Chromosome mutation changes a base.

True
or
False

Answers

Answer:

I think true as then it wouldn't make sense making it a mutatuon.

Yuki has a bowl of ice. She places the ice in a warm room and watches as it melts into liquid water. Yuki then places the liquid water over a Bunsen burner and heats it until it vaporizes. Explain what happens to the water molecules in Yuki's experiment; from the beginning to the end of the experiment.

Answers

Answer:

ice is a solid.When heat is added it turns into a liquid,its a reversible change.As regarding to the water moleculesWhen water is heated, it expands, or increases in volume. When water increases in volume, it becomes less dense. As water cools, it contracts and decreases in volume. When water decreases in volume, it becomes more dense. For samples of water that have the same mass, warmer water is less dense and colder water is more dense.Im not sure if this helps but try it out :)

What advancements helped Earth’s human population to grow so quickly?

Answers

Explanation:

human have increased the world's carrying capacity through migration agriculture Medical advances and Communications. the age structure of a population allows us to predict population growth.unchecked human population could have dire long term effects on our environment.

3. What is an embryo?

a. a small, adult organism

b. a fully developed organism

c. an early stage in the development of an organism

d. the gamete of an organism

Answers

Answer:

c. an early stage in the development of an organism

Explanation:

Answer:

c. an early stage in the development of an organism

Explanation:

In general, in organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization and continues through the formation of body structures, such as tissues and organs

what is an indicator of soil?

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An indicator of soil is Moist dirt

Which of these statements about fungi are true?

Answers

Answer: where are your statements

Explanation:

Answer:
B
Explanation:
Fungal spores (macro- and microconidia) are inhaled and develop into yeast in the lung parenchyma.

Using the research of another scientist without giving proper credit is

A. ethical
B. a liability
C. plagiarism
D. standard practice​

Answers

Answer:

C. Plagiarism

Explanation:

Without quoting/crediting someone's work you are copying and taking their work for yours.

Serious consequences will follow (including jail time)

The Answer Is

C.

It is plagiarism to use someone’s else’s work without proper credit.

Vascular resistance is due to friction between blood and the walls of the blood vessel. Which of the following causes low vascular resistance?
O obesity
O dehydration
O high blood pressure
o cholesterol levels within normal range

Answers

The factor that does not lead to a high vascular resistance is cholesterol levels within normal range.

What is vascular resistance?

The term vascular resistance refers to a situation in which blood finds it difficult to pass through the blood vessels. A lot of factors may lead to this such as the constriction of the blood vessels owing to high cholesterol levels.

From the options that we have in the question, the factor that does not lead to a high vascular resistance is cholesterol levels within normal range.

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Who came up with the theory of continental drift? Was his theory originally accepted by
the scientific community?

Answers

Answer:

scientist Alfred Wegener and no it wasn't accepted .

Explanation:

The main reason that Wegener's hypothesis was not accepted was because he suggested no mechanism for moving the continents. He thought the force of Earth's spin was sufficient to cause continents to move, but geologists knew that rocks are too strong for this to be true. Hope it helps :) , please mark as the brainliest answer .



Various factors influences the fluidity of the phospholipid bilayer of the cell membrane. If we were to chart the composition of cell
membranes in organisms as we move north from the equator to higher latitudes around the Arctic circle, we would expect to find
phospholipids with
A)
fewer hydrophilic heads.
B)
fewer interspersed cholesterol molecules.
both saturated and unsaturated fatty acid tails.
D
an increase in the length of the fatty acid tails.

Answers

Answer:

D

an increase in the length of the fatty acid tails.

Explanation:

As average annual temperatures decrease, we would expect to find phospholipids within the cell membranes of organisms to have both saturated

and unsaturated fatty acid tails. Saturated fatty acids tails are arranged linearly, in a way that maximizes interactions between the tails and

decreases bilayer fluidity. Unsaturated fatty acids, on the other hand, have more distance between the tails, fewer intermolecular interactions and

more membrane fluidity. Longer tails and decreased cholesterol also decrease fluidity

The answer is Going to be D

Which of the following is NOT a strategy
for controlling water pollution?
A hiding storm drains
B, sewage treatment plants
C. water treatment plants
D, maintaining coastal wetlands

Answers

Answer:

A

Explanation:

if you hide a storm drain it really doesn't do much because it doesn't clean the water, and all of the other options do clean water of contaminants.


8. For the food chain shown below, which of the following changes would 2 points
have the most severe consequences? Grasses - Crickets → Field Mice →
Hawks
A minor decrease in rainfall
The field mice population slightly increasing
The introduction of a second predator that eats field mice
0 A parasitic infestation that reduces the cricket population

Answers

Answer:

I think it is A Parasitic one

Explanation:

A decrease in rainfall may lead to drought, thereby altering the basis (first level) of the food web.

A food web is a diagram that represents the relationships between different groups of organisms in an ecosystem.

Producers (e.g., plants) are organisms that maintain the entry of matter and energy to the food web.

Rainfall is fundamental for maintaining the life of land producers (in this case, grasses) in the food web.

In conclusion, a decrease in rainfall may lead to drought, thereby altering the basis (first level) of the food web.

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Please anyone help please help ASAP ASAP please please help

Answers

Answer:

A

Explanation:

the 1st one is the answer

A rainbow is an example of light's _____.
1) refraction
2) reflection
3) absorption
4) transmission

Answers

Answer:

2

Explanation:

Answer:

Refraction is correct.

Explanation:

are eukaryotes made of cells?

Answers

Yes they are hope it helps!!!!!!!!

Answer:

it is a cell

Explanation:

Organisms with prokaryotic cells are called prokaryotes. All prokaryotes are single-celled (unicellular) organisms. Bacteria and Archaea are the only prokaryotes. Organisms with eukaryotic cells are called eukaryotes.

...

Prokaryotic Cells.

Prokaryotic Cells     Eukaryotic Cells

Bacteria                    Plants, animals, fungi

What factors could speed up or slow down cellular respiration

Answers

Answer:

Explanation:

Temperature: At a very high temperature, the rate of respiration decreases with time, and at very low temperature, the respiration rate is insignificant. ...

Carbon dioxide concentration: The higher the carbon dioxide concentration, the lower the rate of respiration.

Lymph is another medium of circulation in the human body. justify

Answers

Answer:

Yes, Lymph is another medium of circulation in the human body

Explanation:

Yes, Lymph is another medium of circulation in the human body. Lymph is part of lymphatic system which in turn is part of the circulatory system. The lymphatic circulatory system comprises of lymphatic vessels which carry clear fluid "lymph" towards the heart. The flow however is unidirectional

what is the meaning of PHIVOLCS?​

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Answer:

Philippine Institute of Volcanology and Seismology. Please vote as the brainliest  , thanks :)

Explanation:

Identify which European nations were successful in trading with Japan before the 1800’s.

Answers

The Dutch were the only one's successful in trading with Japan until the 1800's.

BRAINIEST ANSWER

Just check my answers please

:))

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Answer:

Sand, Gravel and Granite is the Answer.

Explanation:

if it helps don't forget to like and mark me

Answer:

ur correct

Explanation:

I just searched it up

You have a glass of milk and a glass of water you need to pour them into the same container such that the two liquids are differentiated and can be separated how do you do it?

Answers

Answer:

Pour the water first, freeze it, and then pour the milk. The freezing point of raw unprocessed milk is ∼−0.5 degrees Celsius, so by keeping the barrel under 0 degrees, but above −0.5 degrees, you can keep the water frozen and the milk liquid, and be able to separate them.

You can freeze the whole thing below −0.5 degrees. Just don’t warm it suddenly above 0 degrees without separating the milk first.

In fact, the freezing point of milk can be and is used as a test to check whether water was added to milk by producers.

4. Which is not a common poison?

Answers

Answer:

Do you have the options?

Which two characteristics do all forces have?
O motion and size
O size and direction
O direction and speed
O balance and direction

Answers

Answer:

direction and speed are two characteristics of forces

Does anyone know this? Please help! Due in 45 min

Answers

Answer:

I think it's A tell me if it's wrong

hope it helps

have a good day :)

Explanation:

Answer:

D. l,ll, and lll

Explanation:

Hope this helps!


What type of muscle tissue is attached to bone?
Smooth
Cardiac
Striated
Both a & b

Answers

Answer:

striated

Explanation:

skeletal muscle: The voluntary muscle of vertebrates, which is striated and anchored by tendons to bone, is used to effect skeletal movement such as locomotion.

When a wolf eats a rabbit and then uses the energy from the rabbit to
run, the wolf's body converts...
O chemical energy to electrical energy
O mechanical energy to chemical energy
O thermal energy to mechanical energy
chemical energy to mechanical energy

Answers

Answer:

thermal energy to mechanical energy

Explanation:

have a nice day good luck

At the time when a wolf eats a rabbit so here the body should convert chemical energy to mechanical energy

Conversion of energy:

At the time when the wolf eats a rabbit and then uses the energy from the rabbit to run, so here the body should convert chemical energy to mechanical energy.

As the chemical energy treated as the potential energy that stored the food.

hence, the last option is correct.

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Which of the following conditions are required for natural selection?

I. overproduction of offspring

II. competition for resources

III. genetic variation

IV. natural disasters

Answers

Answer:

I think the answer is III. genetic variation

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