An individual has a mutation in the gene that codes for hemoglobin. This results in sickle cell disease. Choose the correct explanation for how this mutation affects the individual's traits.
a. The error in the DNA sequence results in an error in the mRNA molecule during transcription, the error in the mRNA molecule results in an incorrect amino acid in the hemoglobin protein which makes it non-functional. The resulting trait is sickle cell disease.
b. The error in the mRNA sequence results in an error in the DNA molecule during transcription, the error in the DNA molecule results in an incorrect nucleic acid in the hemoglobin protein which makes it non-functional. The resulting trait is sickle cell disease.
c. The error in the DNA sequence results in an error in the mRNA molecule during transcription, the error in the mRNA molecule results in an incorrect nucleic acid in the hemoglobin protein which makes it non-functional. The resulting trait is sickle cell disease.
d. The error in the mRNA sequence results in an error in the DNA molecule during transcription, the error in the DNA molecule results in an incorrect amino acid in the hemoglobin protein which makes it non-functional. The resulting trait is sickle cell disease.

Answers

Answer 1

Answer:

a

Explanation:

The correct answer would be that the error in the DNA sequence results in an error in the mRNA molecule during transcription, the error in the mRNA molecule results in an incorrect amino acid in the hemoglobin protein which makes it non-functional. The resulting trait is sickle cell disease.

The direction of the flow of information during genetic inheritance is from DNA to mRNA and finally to protein. The information in the DNA is encoded into mRNA during transcription and the encoded information is translated into protein during the process of translation.

Hence, once there is an error in the DNA, the error is passed on to the mRNA during transcription. The consequence of this error is that the wrong amino acid is translated from the wrong codon.

Hence, the substitution of the correct amino acid by the wrong one in the hemoglobin protein results in a defect or non-functional protein. One of the phenotypic implications of this kind of error is sickle cell disease.

The correct option is a.

Answer 2

An error in DNA results in an error in mRNA during transcription, thereby resulting in an incorrect amino acid in the hemoglobin protein which makes it non-functional, producing sickle cell disease (Option a).

A mutation is any alteration in the nucleotide (DNA) sequence of the genome of an organism.

During gene transcription, a specific fragment of DNA called 'gene' is used as template to create a complementary RNA sequence known as messenger RNA (mRNA).

Subsequently, this mRNA is used as a template to create a protein in the ribosomes by a mechanism called translation.

The triplets of nucleotides or 'codons' in the mRNA sequence determine the correct order of amino acids that will be added to the growing polypeptide (in this case, the hemoglobin protein).

In conclusion, an error in DNA results in an error in mRNA during transcription, thereby resulting in an incorrect amino acid in the hemoglobin protein which makes it non-functional, producing sickle cell disease (Option a).

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Related Questions

Explain why hormones are able to travel through the body but only affect certain cells.


Answers

Answer:

Hormones are able to travel the body but only affect certain cells because only those target cells have receptors for that particular hormone. Some hormones bind to receptors on the surface of target cells. Others enter the cells and bind to receptors in the cytoplasm or nucleus.

Please help me please


Use Figure 1 Tay-Sachs Disease Pedigree to answer the following questions.



a.Interpret what the Roman numerals in the pedigree diagram represent.


b.Interpret the genotypes of the parents in this diagram.


c.If a person who does not carry the Tay-Sachs disease gene marries offspring II4, what are the possible genotypes for their children?

Answers

Answer:

Please see the answer below

Explanation:

a. The roman numerals represent the various generations in the pedigree.

    I represents first generation

   II represents the second generation

b. The half shaded square and circle representing the parents means that both of them are carriers for the trait in question. Tay-Sachs disease is an autosomal recessive inheritance, assuming the trait is represented by the allele a, the gentoypes of the parents would be Aa and Aa respectively.

c. Still on the assumption that the disease is represented by the allele a. If offpsring II4 which happens to be free of the Tay-Sachs allele marries a person that also does not carry the Tay-Sachs disease gene, the cross will be as shown below.

AA   x   AA = AA, AA, AA, and AA.

All the children would be free from the Tay-Sach's allele. That is, they will be homozygous normal.

Part A:

The roman numerals in the pedigree diagram represent are :

   I = represents first generation

  II = represents the second generation

Part B:

The genotypes of the parents would be Aa and Aa .

Half-shadowed squares and circles that represent the parent mean that both  are carriers of the characteristics of the problem. TaySachs disease is  autosomal recessive when the trait is represented by the allele a.Part C:The possible genotypes for their children are:

       AA   x   AA = AA, AA, AA, and AA.

All the children would be free from the Tay-Sach's allele.

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Ethology is the study of how animals behave towards each other and in response to
their environment.
True
False

Answers

Answer:

True ig.

Explanation:

the science of animal behavior.

the study of human behavior and social organization from a biological perspective.

the answers true, hope that helped

Which of these is an autosomal recessive disorder?

Answers

Answer:

what are the options?

Explanation:

Examples of autosomal recessive disorders are :

Cystic fibrosis

Sickle cell anemia 

Tay Sachs disease

Answer:

Huntington’s disease

Explanation:

It was the answer between

A. Huntington’s Disease

B. Cystic fibrosis

C. Muscular Dystrophy

D. Sickle-cell anemia

The introduction of plastics in to the marine environment has also contributed to what other damages to planetary boundaries. Mark all that

apply

a. Biodiversity loss due to marine animals which are killed through entagling in or consuming plastic waste which reaches the ocean.

b. Biomagnification of mercury pollution in to the food chain through microplastics which absorb the mercury and are then

consumed.

c. An increase in ocean acidification through plastics leeching low pH contaminants in to the water.

d. An increase in carbon dioxide emissions which contribute to climate change through the use of fossil fuels in producing and

shipping plastic products.

Answers

Answer:

Option-A,B and D

Explanation:

Plastic pollution is one of the major threat to the ecosystem on Earth. The increased amount of plastic in the ocean has affected the aquatic ecosystem as it is the cause of the increased number of aquatic animals.

The animals consume the floating plastic of the ocean or get entangled in plastic waste.

The consumed plastic waste becomes a threat to these individuals. The microplastic consumed by the fishes, crabs can disrupt the food chain as it can cause biomagnification.

The plastic products production and transport to various parts of the world also cause harm as these activities involve the use of fossil fuels which leads to an increase in the concentration of carbon dioxide.

Thus, the selected options are correct.

When blood glucose levels rise above the normal range, the pancreas secretes ________, but when blood glucose levels fall below the normal range, the pancreas secretes ________. a.insulin; glucagon b.epinephrine; glucagon c.glucagon; insulin d.epinephrine; insulin e.glucagon; glycogen

Answers

glucose level increase, insulin is secreted.

glucose level decrease, glucagon is secreted

Which system cooperates most closely with the endocrine system?

Answers

Answer:

The nervous system

Explanation:

The brain continuously sends instructions to the endocrine system and in return receives feed back from the endocrine glands. Because of thos intimate relationship, the nervous and endocrine systems are referred to as the neuro endocrine system

Transcription of the developmental gene M is influenced by two different proteins: B and H. Studies of single and double mutants generated the following information:
In mutants lacking B, transcription of M does occur
In mutants lacking H, transcription of M does not occur.
In double mutants lacking B and H, transcription of M does occur.
Based on this information, put these genes in order in a developmental pathway. Use arrows and t-bars between the genes as appropriate. Choose the correct identity of each below.
Gene 1 1st Symbol Gene 2 2nd Symbol Outcome

Answers

Answer:

B --I H >> M transcribed

Explanation:  

Reverse genetics is a classical approach used in molecular genetics to elucidate gene function in a signaling gene network. This technique consists of producing loss of function mutations in genes of interest in order to analyze their phenotypic effects in the downstream signaling pathway.  

In this case, the mutation in B didn't affect the expression of the developmental gene M, together with the other mutant lines, this experiment indicates that B is a downstream suppressor of H (since further experiments show that B plays a role in the signaling pathway). Moreover, the mutation in the gene H affects the expression of M, thereby showing that H acts as a downstream activator of M. Finally, B-H double mutants did neither affect the expression of M, thereby showing that M transcription is dependent of the interaction between B and H.

Knowing that proteins B and H interact with each other, and they influence the expression of the M gene, we can propose the following  developmental pathway      B gene  --|  H gene >>  M gene

------------------------------

Gene pathways refer to the regulation of genes expression by turning them on and off. Many genes and proteins might be involved in this process, each of them playing significant roles in the signaling pathway.

Available data:

The transcription of gene M depends on proteins H and BIf protein B is lacking, gene M is transcriptedIf protein H is lackin, gene M is not transcriptedIf B and H are lackin, gene M is transcripted

According to this information, we can assume that,

The mutation in protein B did not influence the transcription of the gene M because even when B is lacking, the gene is transcripted anyway.

However, we can see that H affected M transcription. The mutation in the H protein influenced the gene transcription.

Mutations in proteins H and B did not influence the transcription of the M gene because, in the absence of both proteins, the gene was expressed.

Probably proteins B and H interact with each other, and this interaction influences the M gene transcription.

The developmental pathway is then as follows,

B gene  --|  H gene >>  M gene

------------------------------------

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Which of the following is a side effect of heat islands?

Drought
Increased precipitation
Lower temperatures and drought
Lower temperatures

Answers

Answer:

Drought is a side effect of heat islands

12
A woman with hemophilia and a man without hemophilia get married. What are the chances that their first child will have hemophilia?
75 percent
50 percent
25 percent
100 percent

Answers

Answer:

50 percent

Explanation:

Hemophilia is a disorder in which blood doesn't clot normally.

Lets consider Xn as hemophilia gene.

So woman affected with hemophilia will have XnXn gene and man not affected with hemophilia will have XY gene.

When they both undergo crossover, genes in child will be XXn (girl -carrier), XXn (girl -carrier), XnY (boy-affected) and XnY (boy-affected).

Parent Gene:

XnXn (affected woman)  

XY (Man not affected)

After crossing over - children gene for first generation:

XXn (girl-carrier) XXn (girl-carrier) XnY (boy- affected)                                   XnY (boy- affected)

Hemophilia is a X - linked recessive disease which means women are only carrier for this disease untill or unless both the X genes are hemophilia gene and man have more chances to get affected as they have only one X - linked gene.

It means 2 out 4 children are affected.

So, there are 50 percet chances that their first child will have hemophilia.

Answer:

50 percent

Explanation:

gradpoint

When hydrogen ions are decreased, is the pH higher or
lower?
wi
and for​

Answers

Answer:

The overall concentration of hydrogen ions is inversely related to its pH and can be measured on the pH scale . Therefore, the more hydrogen ions present, the lower the pH; conversely, the fewer hydrogen ions, the higher the pH.

Can someone help me with this :)

Answers

Answer:

mutualism

Explanation:

they both benefit from each other or both mutually help each other

mutualism is your answer



a) What effects would a drier-than average summer have on a pond

ecosystem?


(b) How is this different from the effects

resulting from draining the pond?

Answers

Answer:would cause the pond to be a little more empty because of evaporation and the lack of replacement

Explanation:

In each of the scenarios, an individual heterozygous for the indicated gene or genes is crossed with an identical heterozygous individual. Predict the number of different phenotypes that would be observed among the progeny of such a cross.

Scenario 1: R is completely dominant to r.
Scenario 2: R is incompletely dominant to r.
Scenario 3: R and s are completely dominant to rand s, respectively: R and S are linked by 10 m.u. and don't interact with each other.
Scenario 4: Genes R and S perform the same finction: R and S are completely dominant to r and s, respectivley' and R and S are unliked.
Scenario 5: R and S are completely dominant to r and s, respectively; R and S are unlinked show dominant epistasis.

Answers

Oi como você está? Decênio 1:

Which answer below correctly identifies the type of change and the explanation for the separation of the iron with sulfur? physical change because even though a color change occured, each solid maintained its original properties, which could be seen as soon as the magnet was applied physical change because no temperature change was observed, which would be an indicator of chemical change chemical change because a color change was observed, which indicated that a new substance was formed chemical change because the results depended on the interaction of two substances

Answers

Answer:

[tex]\boxed{\mathrm{view \: explanation}}[/tex]

Explanation:

Physical change because even though a color change occured, each solid maintained its original properties, which could be seen as soon as the magnet was applied.

Speration of iron with sulfur will not change the properties of the metals, the magnet can be used to check. The color overall changes.

A physical change where each solid maintained its original properties when the magnet was applied is an explanation for the separation of the iron with sulfur. Therefore, the correct statement is option A.

What is physical change?

The separation of iron from sulfur is an example of physical change. A physical change is a change in the physical state without the change in its chemical composition. The iron and sulfur can be physically mixed together and are both solids.

When a magnet is applied, the iron is attracted towards magnet, thereby, separating itself from the sulfur which is also a physical change, as it only causes a change in the appearance not in the chemical composition.

However, chemical changes are due to a change in the chemical composition of a substance that results in the formation of a new substance.

Therefore, physical change is an explanation for the separation of the iron with sulfur.

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Which question about whale sharks is nonscientific?

Answers

Answer: c

does a whale shark like having a large mouth?

Explanation:

Need more info, try adding the list

The absence of which of these will not affect photosynthesis is - oxygen, Carbon dioxide, water, Chlorophyll, light. Give reason

Answers

Answer:

Oxygen

Explanation:

Oxygen is the by product of photolysis during photosynthesis whereby water molecules are split to form protons (H+ ions), electrons and oxygen (by product).

Oxygen is not needed during any of the reactions in photosynthesis and Calvin cycle and will not affect the rate of photosynthesis or possibility of photosynthesis occurring. However, it will affect the process of aerobic respiration instead.

Carbon dioxide is needed in carbon fixation during the Calvin cycle. Without it, 6 carbon sugars cannot be formed.

Water is needed for photolysis to produce protons (maintain the electrochemical gradient) and electrons (to replenish lost electrons)

Chlorophyll are pigments that harvest light energy to excite electrons produced from photolysis of water to be passed down the electron transport chain.

Light is needed as a source of energy to energise the electrons

The governments of many countries have regulations that are designed to prevent the accidental introduction of non-native insects in to their countries this is because in these new habitants the non-addictive

Answers

Answer:

These regulations are aimed at protecting natural resources of the harmful effects of invasive species.

Explanation:

The introduction of invasive species such as, for example, insects, plants, mammals, etc., may have devastating effects on a particular area since they have shown to have the potential to disturb the homeostasis of an ecosystem. These invasions may even limit the available resources for higher trophic levels, thereby producing significant ecological impacts. Moreover, invasive insect species can also lead to important economic damages by destroying economically important plants and crops.

Can someone help me please !!

Answers

Answer:

yeah OK I will be there

Complete the sentences by matching the names of trees to the appropriate blanks. To do this, drag the names on the left into the appropriate blanks in the sentences on the right. Match the words in the left column to the appropriate blanks in the sentences on the right. Terms may be used more than once. Make certain you have filled every blank with a term before clicking Submit. 1. Evergreens are plants that maintain their leaves in all seasons and include trees such as cedar, elm, and pine. 2. Hardwoods reproduce using flowers and have broad leaves; hardwoods include trees such as cedar, elm, and pine. 3. Conifer leaves are generally thin and needle-like, while seeds are contained in cones. Conifers include pine and mango. 4. Deciduous trees lose their leaves seasonally and include trees such as maple and pine.maple
mango
cedar
elm
pine

Answers

Answer:

pine, cedar, and mango,

mango, elm, and maple,

pine and cedar,

maple and elm.

Explanation:

1) Evergreen are seedlings that keep their leaf in all periods and include pine, cedar, and mango trees.

Evergreen is a plant that stays all year round and is still green. There are many various types of juniper plants, including shrubs and trees. Evergreens have many coniferous species (such as fir, hemlock, blue spruce, red cedar), and mango.

2) Hardwoods replicate with petals and also have wide leaves, like mango, elm, and maple.

Hardwoods are created by polymer science in which flowers replicate and have large leaves. A number of plants are nocturnal. Some of the temperate climates lose their leaves each fall as rates drop and inactive in winter, and those of tropical areas will shed the leaf in reaction to temporary or intermittent shortage times.

3) Conifer leaves are stiff and syringe-like in particular, while seedlings are encompassed in cones. The conifers include cedar and pine.

Gymnosperms are conifers. They are cone-bearing seedlings with plant tissues, fruiting trees are all live evergreens.

4) Seasonally, deciduous trees drop their leaves, which include plants such as maple and elm.

Deciduous trees that spend part of each year dropping the leaves. We were also present in warm and subtropical climates all over the globe. Deciduous trees possess large, flat plants that draw a direct sun laser light and necessitate liters of fluids.

1. Evergreens are plants that maintain their leaves in all seasons and include trees such as pine, mango and cedar.

Evergreen plants : They remain green and lives more than one season.

2. Hardwoods reproduce using flowers and have broad leaves; hardwoods include trees such as mango, elm and maple.

Hardwood : They are the matured parts of the plant shoots.

3. Conifer leaves are generally thin and needle-like, while seeds are contained in cones. Conifers include cedar and pine.

Conifers : They bears coned shaped seed plants.

4. Deciduous trees lose their leaves seasonally and include trees such as maple and elm.

Decidous plants : They are flower bearing plants which shed their leaves annually.

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Plants use sunlight to convert nutrients into energy.what form of energy transfer is taking place?

Answers

Answer:

The RADIANT energy of the Sun is converted into CHEMICAL energy by the plants.

Explanation:

The RADIANT energy of then sun is converted into chemical energy by the plants.

The answer is solar energy
Since plants use the solar energy captured by the chlorophyll and converts that solar energy into chemical energy (nutrients).

How many cells does meiosis produce

Answers

Answer: Four daughter cells

Compare the mass of the two objects.

Which statement accurately describes the mass of the watermelon?

The mass of the watermelon is less than 2 kg.
The mass of the watermelon is equal to 2 kg.
The mass of the watermelon is greater than 2 kg.

Answers

Answer:

greater than

Explanation:

the mass of an object is basically how big the watermelon is. usually, watermelons weigh more than 9 kg. imagine going to walmart and picking up a watermelon. at first glance, its purty huge. of course the the mass of an object, the more the weight of said object. since watermelons are pretty big, the overall mass is going to be big as well.

The mass of object is greater than other watermelon.

What is mass of Object?

The mass of an object is basically how big the watermelon is. usually, watermelons weigh more than 9 kg. imagine going to walmart and picking up a watermelon.

At first glance, its purty huge. of course the the mass of an object, the more the weight of said object. since watermelons are pretty big, the overall mass is going to be big as well.

Although weight and mass may appear to be the same thing, they are actually completely different quantities. The total quantity of substance, or "stuff," in an item is its mass. Gravitational pull is what gives a thing weight.

Therefore, The mass of object is greater than other watermelon.

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Why do they conduct autopsies when someone is murdered •to understand the cause of death •to understand the circumstances of death •to understand the toxicology of the the body •to use as evidence in a trial

Answers

Answer:

Explanation:

An autopsy is a routine procedure, usually conducted to determine a person's cause of death. Toxicology tests are usually ordered when someone is the victim of a crime, dies unexpectedly or dies for no obvious reason. The purpose of those is to determine if the deceased was under the influence.

to understand the cause of death

Assignment: lab report

Diffusion across a semi permeable membrane

Paragraph plz

Answers

Answer:

This is the movement of molecules and ions from one medium to another,based on the concentration gradients, diffusion distant and area exposed. The plasma membrane is made up of phospholipid-bi-layer, to regulate what passes through.

However,because most of the molecules that diffuses across the membrane are small,non-polar, the bi -layer can not restrain their movements. O2, CO2 and lipids cross this barrier with ease by simple diffusion. However, polar molecules are restricted from passing through..

Explanation:

Two example of exothermic reaction in our daily life

Answers

Answer:

a burning candle

Iron rusting are both examples of exothermic reactions in our life

Explanation:

Answer:

lighting a candle

Ice Cubes. (When water freezes into ice cubes, the energy is released in the form of heat)

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________1. The part of a photosystem that absorb light energy is its:
A. Thylakoid lumen C. Reaction center
B. Pigment –building protein D. Antenna complexes

Answers

Answer:

A. thylakoid lumen

Explanation:

option A is correct answer

Most rain Falls where on earth

Answers

Answer:

areas near the equator

Explanation:

because they receive sunlight thorought the year by which there is much evaporation where by water vapour condenses and much rain falls

If the surface soil is saturated and precipitation increases, there will be

a. a decrease in the amount of groundwater
b. an increase in the rate of capillarity
c. a decrease in the surface elevation of the lake
d. an increase in the amount of runoff

Answers

The answer would be d.), an increase in the amount of runoff.

Q.17 Which of the following cell types would you expect to be abundant with endoplasmic
reticulum and Golgi bodies?
I. Plasma B cells (produce antibodies)
II. Adipose cells (store fats)
III. Islet of Langerhans cells (secrete insulin)
IV. Red blood cells (transport oxygen)
A) I and II only
C) I and III only
B) III and IV only
D) II and III only​

Answers

Answer: D.

The  E. reticulum and Golgi bodies are concerned with secretion and synthesis of molecular substances e.g protein , lipids and steroid. Therefore these cellular organelles should contain   Plasma B cells  and  Islets of Langerhans.  for protein  hormone synthesis(insulin) and antibodies production

Explanation:

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Rewrite 2/5 book 1/2 hour as a unit rate Journalize the entries to record the following selected bond investment transactions for Starks Products: For a compound transaction, if an amount box does not require an entry, leave it blank. a. Purchased for cash $102,000 of Iceline, Inc. 7% bonds at 100 plus accrued interest of $1,190, paying interest semiannually. b. Received first semiannual interest payment. c. Sold $68,000 of the bonds at 102 plus accrued interest of $520. Your policy says you have 50/100/30 coverage.Check the correct coverage for this policy.$50,000 coverage for all injuries in one accident.$100,000 coverage for all injuries in one accident.$50,000 coverage for all property damage in a single collision.$50,000 coverage for injuries to one person in one accident.$50,000 coverage for damage to a single vehicle in one accident.$30,000 coverage for all property damage in a single collision. 5. There are two boxes. Box A contains6 red balls and 4blue balls and Box B contains 4 redballs and 8 blueballs. A die is rolled, if the number isless than 3, a ballis selected from box A. If the resultis 3 or more, a ballis selected from Box B. Calculate:a) The probability that the ball will bered and selected from Box B. The measure of angle 1 is (3x + 10) and the measure ofangle 4 is (4x - 15)What is the measure of angle 7?2 46 85 713b PLEASE HELP ME KIND SOUL! Look at the picture below to understand everything Hey! How are you?So the problem is below and I have found an answer online, BUT the issue I am having is this:I do not think the given answer is the largest possibility. Since 6 is the largest number, cant I just use that and get a sum of 509.04 > 368.24Pretty please help me! I am begging you, I have lost all my brain cells, please clear VERy clear explanations needed!!! Employees can smoke within what areas of the foodestablishment?-Designated smoking areasOr-Dry food storage and food preparation areas Please help me! Tell the person what to do. Use formal or informal commands.Seora Perez no (tomar) ______ el sol. I need help please! If you know the answer can you explain? Why did the "special economic zones" (SEZs) of China succeed? A: They imposed sanctions on Western nations, including the United States. B: They used foreign investment to stimulate the Chinese economy. C: They focused investments on agriculture instead of industry. D: They encouraged people to move from urban to rural areas. The box is laid on its side and the white label covers 60% of the lateral surface area of the box. Find the length x of the box. VERY IMPORTANT Drag the tiles to the correct boxes to complete the pairs.Match each social class with its role in Japanese feudal society.Words:shogunsamuraidaimyoMatch:warriorwealthy landownerruler An individual wants to have $95,000 per year to live on when she retires in 30 years. The individual is planning on living for 20 years after retirement. If the investor can earn 6% during her retirement years and 10% during her working years, how much should she be saving during her working life A building contractor estimates that her profit in dollars for a tall building will be given by the function:P (h) = -4h2 + 160h,where h represents the numer of floors in the buliding.What height will give the maximum profit? What is the maximum profit?Question to answer: What is the maximum profit?profit isdollars What does the repeated reference to Jerry as the "English Boy" tell us about the setting of this story? a = -3, and c = 7. What is the value of b? Time Remaining C.14:06time 0:14:0677%The stem and leaf diagram shows the ages of 15 office workers.2 3 5Key: 23 represents 23 years old3 4 5 8 8 94 1 2 4 6-7 85 39a) How many workers are over 40 years old?8workersb) What is the median age of an office worker?years oldc) The oldest worker retires and is replaced by a 24 year old.What is the new median age?years old Dividing my dogs age by 4 and adding 6 is the same as dividing my dogs age by 8 and adding 8.StartFraction x Over 4 EndFraction + 6 = StartFraction x Over 8 EndFraction + 8How old is my dog? years old PLZ HELP Thoms restaurant bill is $45 and he leaves a 20 percent tip. What is the total cost for Thoms meal? $20 $54 $65 $90 What advantages did the Tuskegee Airmen bring to battle?